Joule heating involving ion currents through channel proteins
نویسندگان
چکیده
Ion currents associated with channel proteins in the presence of membrane potential are ubiquitous cellular and organelle membranes. When an ion current occurs through a protein, Joule heating should occur. However, this seems to have been largely overlooked biology. Here we show theoretical investigation involving biological processes. We used electrochemical derive Joule’s law for transport protein potential, suggest that heat production absorption can Simulation temperature distribution around single revealed increase was as small <10−3 K, although ensemble suggested exhibit noticeable increase. Thereby, theoretically investigated systems containing ensembles proteins. Nerve is known undergo rapid followed by during action our simulation squid giant axon combined Hodgkin-Huxley model successfully reproduced feature heat. Furthermore, extended theory uncoupling 1 (UCP1), solute carrier family transporter, which important non-shivering thermogenesis brown adipose tissue mitochondria (BATM). Our calculations showed UCP1 comparable literature calorimetry data BATM. likely be one mechanisms thermogenesis.
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ژورنال
عنوان ژورنال: Biophysics and physicobiology
سال: 2023
ISSN: ['2189-4779']
DOI: https://doi.org/10.2142/biophysico.bppb-v20.0030